Publications

32. Kolařík, M.; Santarém, N.; Cordeiro-da-Silva, A.; Tavares, J.; Novák, M.; Rydlová, V.; Korábečný, J.; Brulíková, L.*

Eur. J. Med. Chem. 2027, 321, 119382.
Exploring the Structural Requirements of Fluorinated Benzylidene-Thiazolidinediones for Selective Antitrypanosomal Activity
DOI: 10.1016/j.ejmech.2026.119382

31. Chasák, J.; Vyvlečka, P.; Nemec, I.; Matheeussen, A.; Van Pelt, N.; Cos, P.; Caljon, G.; Kryštof, V.; Brulíková, L.*

Chem. Med. Chem. 2026, 21, 4, e202500951.
Cytotoxicity and Antimicrobial Activity Of GaMF1 Analogues
DOI: 10.1002/cmdc.202500951

30. Kolařík, M.; Ilbeigi, K.; Caljon, G.; Brulíková, L.*

Bioorg. Med. Chem. 2025, 130, -, 118363.
Thiazolidinones and related analogues as efficient antitrypanosomal agents
DOI: 10.1016/j.bmc.2025.118363

29. Chasák, J.; Brulíková, L.*

RSC Adv. 2025, 25, 14337-14353.

Solid-phase synthesis of aryl squaramides using Liebeskind–Srogl cross-coupling

DOI: 10.1039/D5RA02225H

28. Chasák, J.; Janicki, I.; Brulíková, L.*

Eur. J. Med. Chem. 2025, 290, 117526.

The Liebeskind–Srogl cross-coupling reaction towards the synthesis of biologically active compounds

DOI: 10.1016/j.ejmech.2025.117526

27. Chasák, J.; Van Moll, L.; Matheeussen, A.; De Vooght, L.; Cos, P.; Brulíková, L.*

ACS Omega 2024, 9(32), 34808–34828.

The Liebeskind–Srogl Cross-Coupling Reaction as a Crucial Step in the Synthesis of New Squaramide-Based Antituberculosis Agents

DOI: 10.1021/acsomega.4c04314

26. Chasák, J.; Oorts, L.; Dak, M.; Šlachtová, V.; Bazgier, V.; Berka, K.; De Vooght, L.; Smiejkowska, N.; Van Calster, K.; Van Moll, L.; Cappoen, D.; Cos, P.; Brulíková, L.* Bioorg. Med. Chem. 2023, 95, 117504(1-18).

Expanding the squaramide library as mycobacterial ATP synthase inhibitors: innovative synthetic pathway and biological evaluation

DOI: 10.1016/j.bmc.2023.117504

25. Šlachtová, V.; Casaretto, N.; Brulíková, L.; Six, Y.*

Org. Biomol. Chem. 2023, 21(31), 6233-6428.

Bicyclic N-dihalocyclopropylamide derivatives as precursors of nitrogen-containing fused polycyclic systems

DOI: 10.1039/D3OB00643C

24. Dak, M.; Šlachtová, V.; Šebela, M.; Bazgier, V.; Berka, K.; Smiejkowska, N.; Oorts, L.; Cappoen, D.; Brulíková, L.*

Eur. J. Med. Chem. 2022, 244, 114831.

Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function

DOI: 10.1016/j.ejmech.2022.114831

23. Urban, M.; Šlachtová, V.; Brulíková, L.*

Eur. J. Med. Chem. 2021, 212, 113139.

Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis

DOI: 10.1016/j.ejmech.2020.113139

22. Chasák, J.; Šlachtová, V.; Urban, M.; Brulíková, L.*

Eur. J. Med. Chem. 2021, 209, 112872.

Squaric acid analogues in medicinal chemistry

DOI: 10.1016/j.ejmech.2020.112872

21. Chasák, J.; Brulíková, L.*

Molecules 2021, 26(6), 1603.

Polymer-supported synthesis of various pteridinones and pyrimidodiazepinones

DOI: 10.3390/molecules26061603

20. Brulíková, L.; Volná, T.; Hlaváč, J.

ACS Omega 2020, 5(16), 9324-9333.

Bis-Rhodamine B System as a Tin Detector or Molecular Electronics Device

DOI: 10.1021/acsomega.0c00218

19. Šlachtová, V.; Šebela, M.; Torfs, E.; Oorts, L.; Cappoen, D.; Berka, K.; Bazgier, V.; Brulíková, L.*

Eur. J. Med. Chem. 2020, 185, 111812.

Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1

DOI: 10.1016/j.ejmech.2019.111812

18. Machníková. R.; Janovská L.; Brulíková, L.*

J. Mol. Struct. 2020, 1200 (-), 127101. Solid-phase synthetic approach towards new pyrimidines as potential antibacterial agents

DOI: 10.1016/j.molstruc.2019.127101

17. Šlachtová, V.; Chasák, J.; Brulíková, L.*

ACS Omega 2019, 4(21), 19314-19323. Synthesis of various 2-aminobenzoxazoles: the study of cyclization and Smiles rearrangement

DOI: 10.1021/acsomega.9b02702

16. Šlachtová, V.; Janovská, L.; Brulíková, L.*

J. Mol. Struct. 2019, 1183 (-), 182-189.

Solid phase synthesis of new thiazolidinedione-pyrimidine conjugates and their antibacterial properties

DOI: 10.1016/j.molstruc.2019.01.073

15. Šlachtová, V.; Brulíková, L.*

ChemistrySelect 2018, 3 (17), 4653-4662.

Benzoxazole Derivatives as Promising Antitubercular Agents

DOI: 10.1002/slct.201800631

14. Mejdrová, I.; Brulíková, L.*; Volná, T.; Hlaváč, J.*

New Journal of Chemistry 2017, 14, 12178-12189.

Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues

DOI: 10.1039/c7nj03019c

13. Petráček, M.; Brulíková, L.; Motyka, K.; Hlaváč, J.

ChemistrySelect 2017, 2 (24), 7325-7331.

From Study of Catalytic Hydrogenation to Novel Ratiometric pH Indicators with Quinoline Scaffold

DOI: 10.1002/slct.201700913

12. Brulíková, L.; Harrison, A.; Miller, M.J.; Hlaváč, J.

Beilstein J. Org. Chem. 2016, 12, 1949–1980.

Stereo- and regioselectivity of the hetero-Diels–Alder reaction of nitroso derivatives with conjugated dienes

DOI: 10.3762/bjoc.12.184

11. Brulíková, L.; Okorochenková, Y.; Hlaváč, J.

Org. Biomol. Chem. 2016, 14 (44), 10437-10443.

A solid-phase synthetic approach to pH independent rhodamine-type fluorophores

DOI: 10.1039/c6ob01772j

10. Brulíková, L.; Křupková, S.; Labora, M.; Motyka, K.; Hradilová, L.; Mistrik, M.; Bartek, J.; Hlaváč, J.

RSC Adv. 2016, 6, 23242-23251.

Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B

DOI: 10.1039/C5RA20183G

9.      Vaňková, B.; Brulíková, L.; Wu, B.; Krchňák, V.

Eur. J. Org. Chem. 2012, 2012 (26), 5075-5084.

Synthesis of Piperazinones, Piperazines, Tetrahydropyrazines, and Dihydropyrazinones from Polymer-Supported Acyclic Intermediates via N-Alkyl- and N-Acyliminiums

DOI: 10.1002/ejoc.201200591

8.  Brulíková, L.; Hlaváč, J.; Hradil, P.

Curr. Med. Chem. 2012, 19 (3), 364-385.

DNA interstrand cross-linking agents and their chemotherapeutic potential

DOI: 10.2174/092986712803414295

7.  Brulíková, L.; Džubák, P.; Hajdúch, M.; Hlaváč, J.

Carbohydr. Res. 2011, 346 (14), 2136-2144.

Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study

DOI: 10.1016/j.carres.2011.07.026

6.  Brulíková, L.; Hlaváč, J.

Beilstein J. Org. Chem. 2011, 7, 678-698.

Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues

DOI: 10.3762/bjoc.7.80

5.  Brulíková, L.; Džubák, P.; Hajdúch, M.; Lachnitová, L.; Kollareddy, M.; Kolář, M.; Bogdanová, K.; Hlaváč, J.

Eur. J. Med. Chem. 2010, 45 (9), 3588-3594.

Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity

DOI: 10.1016/j.ejmech.2010.05.003

4.  Andersen, N.K.; Chandak, N.; Brulíková, L.; Kumar, P.; Jensen, M.D,; Jensen, F.; Sharma, P.K.; Nielsen, P.¨

Bioorg. Med. Chem. 2010, 18 (13), 4702-4710.

Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2′-deoxyuridines

DOI: 10.1016/j.bmc.2010.05.019

3.  Spáčilová, L.; Džubák, P.; Hajdúch, M.; Křupková, S.; Hradil, P.; Hlaváč, J.

Bioorg. Med. Chem. Lett. 2007, (17), 6647-6650.

Synthesis and Cytotoxic Activity of Various 5-[Alkoxy-(4-nitro-phenyl)-methyl]-uracils in their racemic form

DOI: 10.1016/j.bmcl.2007.09.022

2.  Bertolasi, V.; Hradil, P.; Spáčilová, L.; Muller, A.; Hlaváč, J.

Acta Crystallogr E 2007, (E63), o3805.

5-phenyluridine trihydrate

DOI: 10.1107/S1600536807039414

1.  Spáčilová, L.; Hlaváč, J.; Hradil, P.; Fryšová, I.; Maloň, M.; Soural, M.; Krejčí, P.

J. Heterocyclic Chem. 2006, (43), 1065-1070.

Synthesis of N-amino-3-hydroxy-2-phenyl-4(1H)-quinolinone

DOI: 10.1002/jhet.5570430437