Publications

Chasák, J.; Vyvlečka, P.; Nemec, I.; Matheeussen, A.; Van Pelt, N.; Cos, P.; Caljon, G.; Kryštof, V.; Brulíková, L.*
Cytotoxicity and Antimicrobial Activity Of GaMF1 Analogues
Chem. Med. Chem. 2026, 21 (4), e202500951 (1-17). DOI: 10.1002/cmdc.202500951

Chasák, J.; Janicki, I.; Brulíková, L.*
The Liebeskind–Srogl cross-coupling reaction towards the synthesis of biologically active compounds
Eur. J. Med. Chem. 2025, 290 (-), 117526. DOI: 10.1016/j.ejmech.2025.117526

Chasák, J.; Brulíková, L.*
Solid-phase synthesis of aryl squaramides using Liebeskind–Srogl cross-coupling
RSC Adv. 2025, 25 (-), 14337-14353. DOI: 10.1039/D5RA02225H

Kolařík, M.; Ilbeigi, K.; Caljon, G.; Brulíková, L.*
Thiazolidinones and related analogues as efficient antitrypanosomal agents
Bioorg. Med. Chem. 2025, 130 (-), 118363. DOI: 10.1016/j.bmc.2025.118363

Chasák, J.; Van Moll, L.; Matheeussen, A.; De Vooght, L.; Cos, P.; Brulíková, L.*
The Liebeskind–Srogl cross-coupling reaction as a crucial step in the synthesis of new squaramide-based antituberculosis agents
ACS Omega 2024, 9 (32), 34808–34828. DOI: 10.1021/acsomega.4c04314

Šlachtová, V.; Casaretto, N.; Brulíková, L.; Six, Y.*
Bicyclic N-dihalocyclopropylamide derivatives as precursors of nitrogen-containing fused polycyclic systems
Org. Biomol. Chem. 2023, 21 (31), 6325-6341. DOI: 10.1039/D3OB00643C

Chasák, J.; Oorts, L.; Dak, M.; Šlachtová, V.; Bazgier, V.; Berka, K.; De Vooght, L.; Smiejkowska, N.; Van Calster, K.; Van Moll, L.; Cappoen, D.; Cos, P.; Brulíková, L.*
Expanding the squaramide library as mycobacterial ATP synthase inhibitors: innovative synthetic pathway and biological evaluation
Bioorg. Med. Chem. 2023, 95 (-), 117504(1-18). DOI: 10.1016/j.bmc.2023.117504

Dak, M.; Šlachtová, V.; Šebela, M.; Bazgier, V.; Berka, K.; Smiejkowska, N.; Oorts, L.; Cappoen, D.; Brulíková, L.*
Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function
Eur. J. Med. Chem. 2022, 244 (-), 114831 (1-15). DOI: 10.1016/j.ejmech.2022.114831

Chasák, J.; Šlachtová, V.; Urban, M.; Brulíková, L.*
Squaric acid analogues in medicinal chemistry
Eur. J. Med. Chem. 2021, 209 (-), 112872 (1-23). DOI: 10.1016/j.ejmech.2020.112872

Urban, M.; Šlachtová, V.; Brulíková, L.*
Small organic molecules targeting the energy metabolism of Mycobacterium tuberculosis
Eur. J. Med. Chem. 2021, 212 (-), 113139 (1-17). DOI: 10.1016/j.ejmech.2020.113139

Chasák, J.; Brulíková, L.*
Polymer-supported synthesis of various pteridinones and pyrimidodiazepinones
Molecules 2021, 26 (6), 1603 (1-21). DOI: 10.3390/molecules26061603

Machníková, R.; Janovská, L.; Brulíková, L.*
Solid-phase synthetic approach towards new pyrimidines as potential antibacterial agents
J. Mol. Struct. 2020, 1200 (-), 127101 (1-12). DOI: 10.1016/j.molstruc.2019.127101

Šlachtová, V.; Šebela, M.; Torfs, E.; Oorts, L.; Cappoen, D.; Berka, K.; Bazgier, V.; Brulíková, L.*
Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1
Eur. J. Med. Chem. 2020, 185 (-), 111812 (1-13). DOI: 10.1016/j.ejmech.2019.111812

Brulíková, L.; Volná, T.; Hlaváč, J.*
Bis-Rhodamine B System as a Tin Detector or Molecular Electronics Device
ACS Omega 2020, 5 (16), 9324-9333. DOI: 10.1021/acsomega.0c00218

Šlachtová, V.; Janovská, L.; Brulíková, L.*
Solid phase synthesis of new thiazolidinedione-pyrimidine conjugates and their antibacterial properties
J. Mol. Struct. 2019, 1183 (-), 182-189. DOI: 10.1016/j.molstruc.2019.01.073

Šlachtová, V.; Chasák, J.; Brulíková, L.*
Synthesis of various 2-aminobenzoxazoles: the study of cyclization and Smiles rearrangement
ACS Omega 2019, 4 (21), 19314-19323. DOI: 10.1021/acsomega.9b02702

Šlachtová, V.; Brulíková, L.*
Benzoxazole Derivatives as Promising Antitubercular Agents
ChemistrySelect 2018, 3 (17), 4653-4662. DOI: 10.1002/slct.201800631

Petráček, M.; Brulíková, L.; Motyka, K.; Hlaváč, J.
From Study of Catalytic Hydrogenation to Novel Ratiometric pH Indicators with Quinoline Scaffold
ChemistrySelect 2017, 2 (24), 7325– 7331. DOI: 10.1002/slct.201700913

Mejdrová, I.; Brulíková, L.; Volná, T.; Hlaváč, J.
Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues
New J. Chem. 2017, 14 (-), 12178-12189. DOI: 10.1039/c7nj03019c

Brulíková, L.; Křupková, S.; Labora, M.; Motyka, K.; Hradilová, L.; Mistrik, M.; Bartek, J.; Hlaváč, J.
Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B
RSC Adv. 2016, 6 (-), 23242-23251. DOI: 10.1039/C5RA20183G

Brulíková, L.; Harrison, A.; Miller, M.J.; Hlaváč, J.
Stereo- and regioselectivity of the hetero-Diels–Alder reaction of nitroso derivatives with conjugated dienes
Beilstein J. Org. Chem. 2016, 12 (-), 1949–1980. DOI: 10.3762/bjoc.12.184

Brulíková, L.; Okorochenková, Y.; Hlaváč, J.
A solid-phase synthetic approach to pHindependent rhodamine-type fluorophores
Org. Biomol. Chem. 2016, 14 (44), 10437-10443. DOI: 10.1039/c6ob01772j

Brulíková, L.; Hlaváč, J.; Hradil, P.
DNA interstrand cross-linking agents and their chemotherapeutic potential
Curr. Med. Chem. 2012, 19 (3), 364-385.

Vaňková, B.; Brulíková, L.; Wu, B.; Krchňák, V.
Synthesis of Piperazinones, Piperazines, Tetrahydropyrazines, and Dihydropyrazinones from Polymer-Supported Acyclic Intermediates via N-Alkyl- and N-Acyliminiums
Eur. J. Org. Chem. 2012, 2012 (26), 5075-5084.

Brulíková, L.; Hlaváč, J.
Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues
Beilstein J. Org. Chem. 2011, 7 (-), 678-698.

Brulíková, L.; Džubák, P.; Hajdúch, M.; Hlaváč, J.
Synthesis of Various 5-Alkoxymethyluracil Analogues and Structure-Cytotoxic Activity Relationship Study
Carbohydr. Res. 2011, 346 (14), 2136-2144.

Andersen, N.K.; Chandak, N.; Brulíková, L.; Kumar, P.; Jensen, M.D,; Jensen, F.; Sharma, P.K.; Nielsen, P.
Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2′-deoxyuridines
Bioorg. Med. Chem. 2010, 18 (13), 4702-4710.

Brulíková, L.; Džubák, P.; Hajdúch, M.; Lachnitová, L.; Kollareddy, M.; Kolář, M.; Bogdanová, K.; Hlaváč, J.
Synthesis of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uridines and study of their cytotoxic activity
Eur. J. Med. Chem. 2010, 45 (9), 3588-3594.

Bertolasi, V.; Hradil, P.; Spáčilová, L.; Muller, A.; Hlaváč, J.
5-phenyluridine trihydrate
Acta Crystallogr E 2007, E63, o3805.

Spáčilová, L.; Džubák, P.; Hajdúch, M.; Křupková, S.; Hradil, P.; Hlaváč, J.
Synthesis and Cytotoxic Activity of Various 5-[Alkoxy-(4-nitro-phenyl)-methyl]-uracils in their racemic form
Bioorg. Med. Chem. Lett. 2007, 17, 6647-6650.

Spáčilová, L.; Hlaváč, J. ; Hradil, P.; Fryšová, I.; Maloň, M. ; Soural, M. ; Krejčí, P.
Synthesis of N-amino-3-hydroxy-2-phenyl-4(1H)-quinolinone
J. Heterocyclic Chem. 2006, 43, 1065-1070.